Breast Density 101
For the Dense Population with Dense Breasts: When Mammography WILL NOT Work for you!


Reported as a Negative scan
Positive for an 8mm Malignancy - Biopsy proven

A) Mammogram
B) BSGI
C) Mammogram
D) BSGI
Images: AJR Am J Roentgenol. 2014 Feb;202(2):293-8.
Images courtesy of Rhodes, et al. Radiol 2015;vol258
Molecular Imaging
Images Physiology instead of anatomy...
in other words molecular imaging techniques
don't care about how Dense you are!
1. Breast specific gamma imaging
(AKA: BSGI)
Uses 99mTc Sestamibi which is actively taken up by the
mitochondria in your cancer cells, and emits light from
the area of the highest concentration of cancer cells.
Here is a perfect example of how Molecular Imaging
just does not care about how DENSE you are... it only
cares about your cancer cells.
In the Images over there, you can see how the tumors are
hidden in the mammogram, but are clearly seen as black
spots on BSGI, especially in those dense breasts in A and B.
2. molecular breast imaging
(AKA: MBI)
Also uses 99mTc Sestamibi, but the
difference in Molecular Breast Imaging and
Breast Specific Gamma Imaging (i.e. above)
is that the camera uses a different - NEWER - technology
and is able to find even smaller clusters of cancer cells
taking up the Sestamibi!!!
Molecular Breast Imaging can pick up
even smaller tumors, like this one.........
3. Positron emission mammography
(AKA: PEM)
Uses positron technology (!!!WOW!!!)
to detect actively dividing cancer cells, using
18F-FDG, AKA: RADIOACITVE SUGAR.
This technique is so amazing, it can detect
tumors as small as 2 (yes TWO), millimeters
Positron Emission Mammography Images reveal Extensive DCIS
Mammogram Negative
Images courtesy of Lorraine Tafra, Anne Arundel Medical Center, Annapolis, MD