Breast Density 101
For the Dense Population with Dense Breasts: When Mammography WILL NOT Work for you!


Reported as a Negative scan
Positive for an 8mm Malignancy - Biopsy proven

A) Mammogram
B) BSGI
C) Mammogram
D) BSGI
Images: AJR Am J Roentgenol. 2014 Feb;202(2):293-8.
Images courtesy of Rhodes, et al. Radiol 2015;vol258
Molecular Imaging
Images Physiology instead of anatomy...
in other words molecular imaging techniques
don't care about how Dense you are!
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1. Breast specific gamma imaging
(AKA: BSGI)
Uses 99mTc Sestamibi which is actively taken up by the
mitochondria in your cancer cells, and emits light from
the area of the highest concentration of cancer cells.
Here is a perfect example of how Molecular Imaging
just does not care about how DENSE you are... it only
cares about your cancer cells.
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In the Images over there, you can see how the tumors are
hidden in the mammogram, but are clearly seen as black
spots on BSGI, especially in those dense breasts in A and B.
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2. molecular breast imaging
(AKA: MBI)
Also uses 99mTc Sestamibi, but the
difference in Molecular Breast Imaging and
Breast Specific Gamma Imaging (i.e. above)
is that the camera uses a different - NEWER - technology
and is able to find even smaller clusters of cancer cells
taking up the Sestamibi!!!
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Molecular Breast Imaging can pick up
even smaller tumors, like this one.........
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3. Positron emission mammography
(AKA: PEM)
Uses positron technology (!!!WOW!!!)
to detect actively dividing cancer cells, using
18F-FDG, AKA: RADIOACITVE SUGAR.
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This technique is so amazing, it can detect
tumors as small as 2 (yes TWO), millimeters
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Positron Emission Mammography Images reveal Extensive DCIS
Mammogram Negative
Images courtesy of Lorraine Tafra, Anne Arundel Medical Center, Annapolis, MD